口腔卫生差更易感染HPV
口腔卫生差更易感染HPV。最新的研究表明口腔的卫生条件是人乳头瘤病毒（HPV）感染的独立危险因素。
Cancer Prev. Res. （IF=4.891）的一项最新研究表明，口腔卫生条件差HPV感染增加56%。
该研究调查了3439名30～69岁之间的成人，发现患有牙龈疾病的人HPV感染率增加51%；患有牙齿疾病的人HPV感染率增加28%。男性比女性更易感染HPV（12% VS 3%）。
吸食大麻者同样与HPV感染有关，研究发现未吸食大麻者口腔HPV感染率仅有5%，既往吸食过大麻者HPV感染率为8%，而现在还吸食大麻者HPV感染达14%。
以往的研究认为口交、性伴数量以及吸烟与口腔HPV感染率增加有关。过去Bui博士及其团队也进行过类似研究，的确发现口交和吸烟与HPV感染率增加有关。本次使用多重加归发现口腔卫生差是口腔HPV感染率增加有独立危险因素。
Bui博士称：「好消息是这种危险因素是可以改变的。如果保持口腔卫生，就会避免HPV感染以及HPV相关的癌症」。
本研究的意义不仅在于改善口腔卫生可以降低口腔HPV感染率，而且还可以降低口腔癌症的发病率。研究发现，口腔HPV感染与口腔40%～80%的癌症发病有关。因此，口腔卫生条件改善了，HPV感染率就降低，口腔癌症的发病率也随之减少。
因此为了自己的健康，保持口腔卫生是必要的。
Oral human papillomavirus (HPV) infection is the cause of 40% to 80% of oropharyngeal cancers; yet, no published study has examined the role of oral health in oral HPV infection, either independently or in conjunction with other risk factors. This study examined the relation between oral health and oral HPV infection and the interactive effects of oral health, smoking, and oral sex on oral HPV infection.
Our analyses comprised 3,439 participants ages 30 to 69 years for whom data on oral HPV and oral health were available from the nationally representative 2009–2010 National Health and Nutrition Examination Survey.
Results showed that higher unadjusted prevalence of oral HPV infection was associated with four measures of oral health, including self-rated oral health as poor-to-fair [prevalence ratio (PR) = 1.56; 95% confidence interval (CI), 1.25–1.95], indicated the possibility of gum disease (PR = 1.51; 95% CI, 1.13–2.01), reported use of mouthwash to treat dental problems in the past week (PR = 1.28; 95% CI, 1.07–1.52), and higher number of teeth lost (Ptrend = 0.035). In multivariable logistic regression models, oral HPV infection had a statistically significant association with self-rated overall oral health (OR = 1.55; 95% CI, 1.15–2.09), independent of smoking and oral sex.
In conclusion, poor oral health was an independent risk factor of oral HPV infection, irrespective of smoking and oral sex practices. Public health interventions may aim to promote oral hygiene and oral health as an additional measure to prevent HPV-related oral cancers.
参考文献：Thanh Cong Bui et. al. Examining the Association between Oral Health and Oral HPV Infection. Cancer Prev Res; 6(9); 1–8.
口腔HPV感染相关因素
Cancer Prev. Res. （IF=4.891）的一项最新研究表明，口腔卫生条件差HPV感染增加56%。
该研究调查了3439名30～69岁之间的成人，发现患有牙龈疾病的人HPV感染率增加51%；患有牙齿疾病的人HPV感染率增加28%。男性比女性更易感染HPV（12% VS 3%）。
吸食大麻者同样与HPV感染有关，研究发现未吸食大麻者口腔HPV感染率仅有5%，既往吸食过大麻者HPV感染率为8%，而现在还吸食大麻者HPV感染达14%。
以往的研究认为口交、性伴数量以及吸烟与口腔HPV感染率增加有关。过去Bui博士及其团队也进行过类似研究，的确发现口交和吸烟与HPV感染率增加有关。本次使用多重加归发现口腔卫生差是口腔HPV感染率增加有独立危险因素。
Bui博士称：「好消息是这种危险因素是可以改变的。如果保持口腔卫生，就会避免HPV感染以及HPV相关的癌症」。
本研究意义
本研究的意义不仅在于改善口腔卫生可以降低口腔HPV感染率，而且还可以降低口腔癌症的发病率。研究发现，口腔HPV感染与口腔40%～80%的癌症发病有关。因此，口腔卫生条件改善了，HPV感染率就降低，口腔癌症的发病率也随之减少。
因此为了自己的健康，保持口腔卫生是必要的。
Abstract
Oral human papillomavirus (HPV) infection is the cause of 40% to 80% of oropharyngeal cancers; yet, no published study has examined the role of oral health in oral HPV infection, either independently or in conjunction with other risk factors. This study examined the relation between oral health and oral HPV infection and the interactive effects of oral health, smoking, and oral sex on oral HPV infection.
Our analyses comprised 3,439 participants ages 30 to 69 years for whom data on oral HPV and oral health were available from the nationally representative 2009–2010 National Health and Nutrition Examination Survey.
Results showed that higher unadjusted prevalence of oral HPV infection was associated with four measures of oral health, including self-rated oral health as poor-to-fair [prevalence ratio (PR) = 1.56; 95% confidence interval (CI), 1.25–1.95], indicated the possibility of gum disease (PR = 1.51; 95% CI, 1.13–2.01), reported use of mouthwash to treat dental problems in the past week (PR = 1.28; 95% CI, 1.07–1.52), and higher number of teeth lost (Ptrend = 0.035). In multivariable logistic regression models, oral HPV infection had a statistically significant association with self-rated overall oral health (OR = 1.55; 95% CI, 1.15–2.09), independent of smoking and oral sex.
In conclusion, poor oral health was an independent risk factor of oral HPV infection, irrespective of smoking and oral sex practices. Public health interventions may aim to promote oral hygiene and oral health as an additional measure to prevent HPV-related oral cancers.
参考文献：Thanh Cong Bui et. al. Examining the Association between Oral Health and Oral HPV Infection. Cancer Prev Res; 6(9); 1–8.
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